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51.
Federico Cismondi Abigail L. Horn André S. Fialho Susana M. Vieira Shane R. Reti João M.C. Sousa Stan Finkelstein 《Expert systems with applications》2012,39(16):12332-12339
In many binary medical classification problems, the cost of misclassifying one category is higher than the other, and in these applications it is desirable to employ a classifier with selective sensitivity or specificity. This work explores the utility of a fuzzy multi–criteria function for performance evaluation during knowledge–based medical classification and prediction. The method presented here uses fuzzy optimization to combine the sensitivity, specificity, and accuracy of classification as goals in a single objective function. This approach is used to assign flexible goals, which can be used to maximize the outcome in terms of each one of the goals. The proposed approach significantly increases the sensitivity and the specificity while maintaining or increasing accuracy. The versatility of the method is further exploited in a multi-model approach, using individual structures of multi-objective optimization of sensitivity and specificity separately, and then combining their outcomes through a decision-making module. Among various medical benefits derived from applying this technique, the divergent feature sets selected by high sensitivity and specificity models lend insight into factors more integrally connected to what causes risk of death for patients. 相似文献
52.
This paper presents a novel agent architecture, the VM-architecture, that chooses its actions via a behaviour instantiation mechanism inspired by Maes?s behaviour networks. The VM-architecture enables an agent, VMattie, built upon it, actively to gather information from humans using email in natural language, to compose announcements of next week?s seminars and to mail them each week to a list that she keeps updated. VMattie does all this without the supervision of a human. Implemented and tested in a UNIX environment, the system?s performance surpassed the authors? fondest hopes. 相似文献
53.
The authors investigated the contribution of the nucleus accumbens (NAc) core and shell to effort-based decision making using a discounting procedure. Selection of 1 lever delivered a smaller, 2-pellet reward immediately, whereas the other lever delivered a 4-pellet reward after a fixed ratio of presses (2, 5, 10, or 20) that increased over 4 blocks of 10 discrete choice trials. Subsequent testing employed an equivalent delays procedure, whereby the relative delay to reward delivery after selection of either option was equalized. In well-trained rats, inactivation of the core, but not the shell, via infusion of GABA A/B agonists muscimol/baclofen reduced preference for the high-effort option under standard conditions and also when rats were tested using an equivalent delays procedure. However, inactivation of the core did not alter preference for 4-pellet versus 2-pellet rewards when the relative costs of each option were the same (1 press). Thus, the NAc core, but not the shell, appears to be part of a neural circuit that biases choice toward larger rewards associated with a greater effort cost. Furthermore, the contributions by the NAc core to this form of decision making can be dissociated from its role in delay discounting. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
54.
This paper describes LEW (learning by watching), an implementation of a novel learning technique, and discusses its application to the learning of plans. LEW is a domain-independent learning system with user-limited autonomy that is designed to provide robust performance in realistic knowledge acquisition tasks in a variety of domains. It partly automates the knowledge acquisition process for different knowledge types, such as concepts, rules, and plans. The inputs to the system, which we call cues , consist of an environmental component and of pairs containing a problem and its solution. Unlike traditional forms of "learning from examples", in which the system uses the teacher's answer to improve the result of a prior generalization of an example, LEW treats the problem-solution or question-answer instances, i. e., the cues themselves, as the basic units for generalization. 相似文献
55.
An organizational prototype is a forum to address simultaneously process, behavioral, and cultural change pursuant to business process redesign (BPR). in this case study, IS personnel facilitated organizational prototypes, thereby extending their knowledge of business systems to a new sphere, facilitating business process redesign. Success of the prototypes led to success in obtaining corporate funding for new client/server systems to support the changes in business operations. 相似文献
56.
A new method for the qualitative and quantitative determination of trenbolone and testosterone residues in meat, liver, and kidney is described. The analytical procedure consists of the following steps: homogenisation of the meat sample with tetrahydrofurane; liquid-liquid partition first between acetonitrile and hexane, then between sodium hydroxide and petroleum ether/benzene; purification of a silica gel column. The purified sample is analysed by high pressure liquid chromatography using silica gel packings. Detection and quantitative determination are performed with a fluorescence and/or a spectrophotometric detector. Fluorescence measurements are carried out applying a self-made silica gel packed flow-cell. The detection limit in meat extracts is 50 ppb for testosterone and 5 ppb for trenbolone. 相似文献
57.
随着可换镜头类单反相机在市场上风生水起,影像业界的知名大厂商索尼(SONY)也耐不住寂寞了。2010年6月9日,索尼在北京发布了基于全新E-mount卡口的新品NEX-5C,被誉为微单相机的它采用了与可换镜头类单反相机一样的光学结构,还配有APS-C画幅的传感器。 相似文献
58.
Production of pharmaceuticals: Amines from alcohols in a continuous flow fixed bed catalytic reactor
Gareth W. Lamb Firas A. Al Badran Jonathan M.J. Williams Stan T. Kolaczkowski 《Chemical Engineering Research and Design》2010,88(12):1533-1540
This paper reports the use of an immobilised ruthenium complex in a continuous flow process for the N-alkylation of morpholine with benzyl alcohol. The ruthenium-based catalyst was supported on a phosphine bound polymer. Screening experiments were first performed in a batch reactor, with a 16 vol% mixture of morpholine and benzyl alcohol (stoichiometric molar ratio of 1:1) in toluene as the solvent. Operating at 110 °C for 24 h, it was shown that high conversions (>99%) into the desired tertiary amine could be achieved. This reaction was then shown to be viable in a continuous flow reactor, where the catalytic polymer beads were retained in the bed. Operating at 150 °C and using p-xylene as a solvent, the conversion into the desired tertiary amine was shown to be as high as 98%. This approach is clearly very promising, as it provides a greener and more atom efficient route for the production of secondary and tertiary amines in the pharmaceutical industry. 相似文献
59.
Vangal S. Anders M.A. Borkar N. Seligman E. Govindarajulu V. Erraguntla V. Wilson H. Pangal A. Veeramachaneni V. Tschanz J.W. Ye Y. Somasekhar D. Bloechel B.A. Dermer G.E. Krishnamurthy R.K. Soumyanath K. Mathew S. Narendra S.G. Stan M.R. Thompson S. De V. Borkar S. 《Solid-State Circuits, IEEE Journal of》2002,37(11):1421-1432
A 32-bit integer execution core containing a Han-Carlson arithmetic-logic unit (ALU), an 8-entry /spl times/ 2 ALU instruction scheduler loop and a 32-entry /spl times/ 32-bit register file is described. In a 130 nm six-metal, dual-V/sub T/ CMOS technology, the 2.3 mm/sup 2/ prototype contains 160 K transistors. Measurements demonstrate capability for 5-GHz single-cycle integer execution at 25/spl deg/C. The single-ended, leakage-tolerant dynamic scheme used in the ALU and scheduler enables up to 9-wide ORs with 23% critical path speed improvement and 40% active leakage power reduction when compared to a conventional Kogge-Stone implementation. On-chip body-bias circuits provide additional performance improvement or leakage tolerance. Stack node preconditioning improves ALU performance by 10%. At 5 GHz, ALU power is 95 mW at 0.95 V and the register file consumes 172 mW at 1.37 V. The ALU performance is scalable to 6.5 GHz at 1.1 V and to 10 GHz at 1.7 V, 25/spl deg/C. 相似文献
60.